Der Pharmacia Lettre
Abstract
Author(s): Karunakar Hegde, Arun B Joshi
Carissa spinarum Linn. (Family: Apocynaceae) has been used traditionally for the treatment of
inflammation-related disorders such as rheumatic pain and to relieve fever. In the present study
the ethanolic extract of the roots of Carissa spinarum (ERCS) was evaluated for its
phytochemical screening and antipyretic activity. Wistar albino rats were induced with Brewer�¢����s
yeast (2 ml/kg, S.C.) for pyrexia and antipyretic activity was assessed with 100, 200 and 400
mg/kg, p.o. ethanolic extract. The ethanolic extract significantly (P <0.05) reduced the elevated
body temperature in a dose dependent manner. The presence of wide varieties of
phytoconstituents may attribute to the promising antipyretic activity of Carissa spinarum root
extract.
