The present paper focuses on the phytochemical screening and antimicrobial activity of Leonotis nepetifolia (Lamiaceae). In the present study the Petroleum ether, Ethyl acetate and methanol extracts of leaves,stem, inflorescence and root of Leonotisnepetifolia were studied for theirantibacterialactivity by agar disc diffusion against both gram positive, gram negative and one fungal strain. It was observed that alcoholic extracts of leaf showed highest antimicrobial activity against the pathogenic microorganisms followed by inflorescence, root and stem extracts. Phytochemical examination indicated the presence of alkaloids, saponins, tanninsand terpenoids.
