The present study was carried out to evaluate the antibacterial properties of Antigonon leptopus against certain gram positive bacterial strains (Bacillus subtilis, Bacillus peritolis and Salmonella typhi) using disc diffusion method. The flower extracts of Antigonon leptopus were prepared using different solvents like ethanol and chloroform and are screened for its antibacterial activity. The best suitable extract was further optimized from the results of antibacterial studies. The phytochemical screening of the flower extracts was performed. The antibacterial activities of ethanol extract and chloroform extract of Antigonon leptopus flowers are checked by disc diffusion method. Both the flower extracts exhibited significant inhibition. Comparative study of the results obtained from the above methods indicates that the ethanol extract shows better antibacterial activity against these strains. All the extracts showed concentration dependent activity comparable with the reference Drug Streptomycin.
