Reducing neonatal mortality is a crucial step for the Millennium Development Goal (MDG-4) to be achieved with neonatal mortality represents over 40% of infant mortality and one quarter of under-five mortality. This study was designed retrospectively to determine the predictors of neonatal morbidity and mortality in tertiary hospital in Ogun State, Nigeria. Purposive sampling technique was used to select all neonates who were admitted at neonatal unit of the hospital. A checklist was used to collect data for period of 6weeks and descriptive and inferential statistics were used to analyze the data generated. Findings of the study revealed that out of the 775 cases analyzed, morbidity and mortality were higher in out-born than inborn and in males than females. Most death occurred in the early neonatal period. There was significant association between place of delivery and management outcome of the neonates as well as significant association between place of delivery and Level of education of mothers of neonates under study with p<0.05. It was recommended that pregnant women should be educated and encouraged to make use of antenatal clinic throughout period of pregnancy and to deliver their babies in the hospital with adequate resuscitation facilities
