Prediction of the antifungicidal activity of few heterocyclic compounds having antituberculastic moieties has been made by using openstate 4 version 6.5.1 statistical software. The studies were carried out on nine analogs. These studies produced good predictive models and give statistically significant correlations of hydrophobic and molar refractivity in R position of the compounds, which having significant correlation with all the fungi strains.