Dengue is one of the most rapidly spreading vector-borne diseases in the world. It affects many countries, especially the ones in the tropical areas like Philippines, Cambodia, Malaysia, India, Indonesia, Thailand, Brazil, Argentina, Eastern Africa and Nigeria, just to name a few. Methods for exterminating the adult mosquitoes involve fumigation, bug zappers, mechanical pest control, and use of adulticides; all of which have been shown to be either inefficient, toxic or both. To circumvent the problems posed by the other methods, the usage of botanical or plant derive products can be done instead. In this study, the larvicidal activities of ethanolicC. frutescent fruit extract and its partially purified fraction – using normal phase column chromatography – were tested against two primary dengue vectors, A. aegyptiand A. albopictus. The LC50 and LC90 after 24 and 48 hours of exposure were approximated using probit analysis. It was found out that the partially purified fraction was more active than the crude extract, by having higher average percent mortality and lower LC50 and LC90. Phytochemical screening of the extract and fraction showed positive for tannins, alkaloids, coumarins, indoles and steroids in both and flavonoids in the crude extract only.
