Learning and memory impairment is the deficits in the memory conditions. The ability to find objects, recall previous locations and navigate throughout the world is dependent upon spatial learning and memory. Cognitive deficits have long been recognized as severe and consistent neurological disorders associated with numerous psychiatric and neurodegenerative states. Experimental models of human disease are used to study pathophysiological factors involved in learning and memory. This study explains the most useful model for the evaluation of memory impairment The present study investigate the Learning and Memory activity of poly herbal methanolic extraction (Rhodiola Rodantha Rhizomes, Blepharis Maderaspatensis seed, Celastrus Paniculatus whole Plant , Brassica Caulorapa Bud) by using Active avoidance paradigm, Passive avoidance paradigm, Scopolamine-induced amnesia, Sodium nitrite intoxication method to assess the nootropic activity.
