Though the seeds of Psidium guajava is edible and consumed along with the edible part of the fruit, it was not evaluated for its pharmacological activities fully. Hence the seeds of the guava fruit are evaluated for Phytochemical and pharmacological evaluation and found many constituents like, fixed oil, sugars, anthocyanins, amino acids and remarkable anti diabetic activity for its alcohol and ethyl acetate extracts. These activities are dose dependent and at higher doses Ethyl acetate extract has even better activity than the standard.