In the present study, photoreaction of khellin with oleic acid methyl ester (OAME) was investigated to seek information parallel to the photobiologically relevant 8-MOP-fatty acid Photocycloaddition. Khellin and oleic acid methyl ester were dissolved in methanol and the solution was deaerated by bubbling with nitrogen gas for about 1 hr and irradiated for 72 hr in a photochemical reactor. Progress of the reaction was monitored by thin layer chromatography (chloroform-methanol, 98:2). At the end of the reaction formation of a number of products was indicated on TLC. The two major photoproducts were isolated by eluting with dichloromethaneethyl ether (1:1, v/v) on a silica column. The products were identified as 3 and 4 from their spectral properties.
