The present study mainly focuses on the ethnomedicinal importance of Atrocarpus hetrophyllus by the regional tribes of Orissa state, India. The selected plant was reported to have wide ethnomedicinal use. The literatures revealed that there is lack of scientific reports on its leaf. So it is important to provide scientific means in a systematic manner. The Microscopic study revealed the presence of Upper Epidermis, Mesophyll, Upper Palisade, Spongy Parenchyma, Parenchymatous cells having intracellular space. Lower Epidermis, Midrib, Vascular bundle, Collenchyma, Cortical parenchyma. The powder microscopy of the plant stated about the presence of Annular vessel, Cluster crystals, Medullary rays, Gramineous stomata .The Phytochemical analysis of the plant has stated about the presence of alkaloids, proteins, tannins, flavanoids etc.The ethnomedicinal documentation confirms about the potent activity of the leaf part of Atrocarpus hetrophyllus.