Der Pharmacia Lettre
Abstract
Author(s): Sudarshan Singh, Dr Sunil B Bothara, Sangeeta Singh, Roshan D. Patel, Naveen K. Mahobia
Cassia tora (Cassia obstusifolia L) is a common herbaceous annual occurring as a weed
throughout India and belongs to the family of Caesalpiniaceae. Seeds of plant contain glucomannose
hence attempt to evaluate the seeds for suitability as tablet binder is considered and the
present investigation repots the isolation of mucilage of Cassia tora seed. The DSC and FTIR
thermograms of drug and gum indicated no chemical interaction. Phytochemical characteristics
of mucilage such as carbohydrate, protein, fat and flavanoids etc. were studied. Physiochemical
characteristics of mucilage such as solubility, swelling index, loss on drying, viscosity, hydration
capacity, powder porosity, microbiological properties and pH were studied. The mucilage was
evaluated for its granulating and binding properties in compressed tablet using Zidovudine as
model drug. Mucilage was used in four different concentrations i.e. 2.0, 4.0, 6.0 and 8.0% w/v.
The granules were prepared by wet granulation process. The prepared granules were evaluated
for percentage of fines, average particle size, compressibility index and flow properties. The
properties were compared with Guar gum which was used as standard binder at 8.0% w/v
concentration. The tablet were prepared and evaluated for content uniformity, hardness,
friability, disintegration time and in vitro dissolution profile. The tablets had good
physiochemical properties and the drug release was more than 85% within 4 hour. It was
observed that increasing the concentration of mucilage increases hardness and decreases the
disintegration time. All the formulations (F1, F2, F3, F4 and F5) were subjected to stability
studies for three months at 25Ã?â??Ã?°C/60% RH, 30Ã?â??Ã?°C/65% RH and 40Ã?â??Ã?°C/75% RH as per ICH
guidelines all four formulation showed stability with respect to release pattern and other
parameters which confirm the use of mucilage as excipient.
