Der Pharmacia Lettre
Abstract
Author(s): Atul A. Bodkhe, Sagar Rase, Prashant Zurao and Anil V. Chandewar
This study was carried out to develop an oral colon specific, tablet to achieve site specific
release of ornidazole and ciprofloxacin hydrochloride. The basic design consists of coating of
ornidazole with eudragit to form microgranules and compressing the ciprofloxacin hydrchloride
powder into a tablet to release the ciprofloxacin hydrochloride in the stomach and finally with
film coating for stability and esthetic appeal. The ornidazole was enteric coated, so that the
variability in gastric emptying time can be overcome and a colon-specific release can be
achieved. The ornidazole microgranules were prepared with EudragitÃ?â??Ã?®L-100, by varying drug
to polymer ratio and evaluated for the particle size, drug content and in vitro release profile and
from the obtained results; one better formulation was selected for further fabrication of tablet.
The aim behind developing this formulation was that when any patient suffers from amebiasis,
can be treated with conventional ornidazole tablet for instant release but after that the organism
resides at the lower GIT(colon) in the dormant phase and many times relapse of the condition
occur with the patient. Thus it can be avoided by targeting the drug at the colon after the initial
treatment.
