Context: Various targeted and modified drug delivery systems have been developed to overcome the challenges for BCS Class IV drug and to obtain a promising drug delivery system. Objective: The present work is aimed to enhance the permeability and solubility of furosemide, an antihypertensive drug by using bile salt as permeation enhancer as well as by formation of cyclodextrin inclusion complex with β- cyclodextin. Method: Furosemide multipolymericbuccoadhesive bilayer films for systemic delivery of furosemide were prepared using solvent casting method. The multipolymeric film contained Chitosan (CH), polyvinyl pyrollidone (PVP) K30, glycerol, sodium glycocholate (SGC) and inclusion complex. A 22 full factorial design was employed to study the effect of independent variables like concentration of CH (x1) and SGC (x2), which significantly influenced permeability of drug. Steady state flux (JSS) was chosen as dependent variable. Result: It was found that the film having higher concentration of CH and SGC (P2) showed high values for JSS. Incorporation of inclusion complex further increased the solubility of furosemide. Conclusion: The present approach for permeation and solubility enhancement using transbuccal route can be further explored for systemic delivery of BCS Class IV drugs.
