In an effort to help people get real benefit of the effectiveness of medicinal plants which are less expensive and affordable, an hydroalcoholic extract of Terminalia ivorensis coded TEKAM2 has been improved and the extracts obtained were tested on the in vitro growth of Candida albicans and Aspergillus fumigatus. The antifungal tests were performed on Sabouraud medium in which the plant extract were incorporated according to the method of inclined tube double dilution. Concentrations ranging from 390 to 1.52 μg /mL. The results showed that all extracts tested have led to a significant inhibition of in vitro growth of C. albicans and A. fumigatus. Among these extracts, the fraction F8 has the best antifungal activity with the lowest antifungal parameter values on C. albicans (MFC = 6.09 μg /mL and IC50 = 1.8 μg /mL) and A. fumigatus (MFC = 3.04μ g / mL and IC50 = 0.36μ g /mL). Fraction F8 is more active on the latter strain.Therefore Fraction F8 concentrates the active molecules of TEKAM 2 better.
