The objective of present study was development and optimization of floating microspheres of famotidine. The floating microspheres can be prepared for the improvement of absorption and bioavailability of famotidine by retaining the system in the stomach for prolonged period of time. The FDDS of famotidine were prepared by different techniques, i.e. polymer phase-separation method, multiple emulsions–water–in-oil-in-water method, oil-in-water emulsion method by using ethyl cellulose and HPMC polymers in same concentration (1:1). Microspheres were evaluated for particle size, drug loading entrapment efficiency and in-vitro drug release. The results obtained from in-vitro dissolution studies were fitted into various kinetic models. The drug release kinetics was best expressed by Higuchi model.
