Hydrogel is a sort of hydrophilic delicate material with a three-dimensional organization structure and has an expansive application prospect in the field of medication. The injury dressings to meet the center requirements are the looking for objectives of researchers. Characteristic organic materials have incredible biocompatibility. In our examination, Human-like collagen-hyaluronic corrosive carboxylated chitosan (HLC-HA-CCS) complex hydrogels crosslinked with glutamine aminotransferase (TG) are ready for wound dressing. HA raises the compressive pressure, CCS expands the counter distortion, HA and CCS together add to improve the porosities, growing and water maintenance properties. Full thickness skin deformity tests show that HLC-HA-CCS hydrogels can advance injury mending in examination with conventional ones. Notwithstanding, the mechanical properties of hydrogels produced using common materials are helpless 2 , and the antimicrobial, saturating execution just as microorganisms opposition neglect to meet the necessities of wound mending. Subsequently, a twofold layer polyvinyl liquor polyethylene glycol-sodium carboxymethyl cellulose (PVA-CMC-PEG) hydrogel are set up to take care of the above issues. The twofold layer hydrogels present a tight upper layer with more modest pore size and a free lower layer with bigger pore size, which can meet the ingestion of drainage and microbes opposition simultaneously. The pore size at the longitudinal segment presents a pattern of continuous decrease and the two layers are fortified firmly. Moreover, the twofold layer hydrogels have a reasonable water fume transmission rate, astounding saturating impact, microbes obstruction capacity and are non-clingy to the injury. Furthermore, the hydrogel have no poisonous consequences for cells. Full-thickness skin imperfection explore shows that the twofold layer PVA-CMC-PEG hydrogels canenhance wound mending extraordinarily and would be ideal injury dressings
