Infrequent invasive pulmonary adenocarcinoma subtype LPA stands for lepidic adenocarcinoma (ADC). The prognostic variables and clinicopathological characteristics of LPA haven’t been fully understood, nevertheless. To investigate the clinicopathological and prognostic characteristics of LPA, data from the Surveillance, Epidemiology and End Results (SEER) database of 4087 LPA patients were retrospectively evaluated and compared with nonLPA pulmonary ADC. To find independent survival variables for additional nomogram development, univariate and multivariate Cox proportional hazard models were run. In both the training and validation cohorts, the concordance index, receiver operating characteristic curves, calibration plots, decision curve analysis, and calibration plots were used to validate the nomograms. Females and elderly patients have a higher likelihood of having LPA. The clinicopathological characteristics of LPA are smaller tumor size, lower histological grade, and stage, which may suggest a positive prognosis. The created nomograms successfully forecast how long LPA patients will live.
