A simple, selective, linear, precise and accurate RP-HPLC method was developed and validated for rapid assay of Cefaclor in Bulk and Pharmaceutical tablet Formulation. Isocratic elution at a flow rate of 1ml/min was employed on symmetry Shimadzu LC-20 ATVP Kromasil C-18 column Column at ambient temperature. The mobile phase consisted of Acetonitrile : Orthophosphoric acid (1%) : 0.01M Ammonium Dihydrogen Phosphate (50:45:5 v/v). The UV detection wavelength was 270nm and 20 μl sample was injected. The run time for Cefaclor is 10 min. The flow rate was found to be 1ml/min. The percentage recovery of the method was found to be 104.35%. The LOD and LOQ for Cefaclor was found to be 40μg/ml and 75μg/ml respectively.The method was validated as per the ICH guidelines. The method was successfully applied for routine quality control analysis of pharmaceutical formulation. The HPLC method can be successfully applied for the routine quality control analysis of Cefaclor formulations, which could be the better choices compared to the reported methods of literature
