The present study was aimed to evaluate neuropharmacological profile of ethanolic extract of Adiantumcapillusveneris (L) by using wide pharmacological activities, i.e. anticonvulsant activity, antidepressant activity, skeletal muscle relaxant activity and analgesic activity. Neuropharmacological profile of ethanolic extract of Adiantumcapillusveneris (L) was evaluated by using different screening models, i.e. anticonvulsant activity by Maximal electro shock induced seizures and Pentylenetetrazole induced convulsions model, antidepressant activity by forced swim test, skeletal muscle relaxant activity by Rota rod apparatus and analgesic activity by Eddy’s hot plate method and tail immersion method in wistar albino mice. The ethanolic extract of Adiantumcapillusveneris (L) showed anticonvulsant activity by prolonging the onset of seizures and reducing the duration of seizures in a significant manner when compared with control group in PTZ induced convulsion model, also by reducing the time for various phases of seizure in MES induced seizures test. Ethanolic extract showed significant depressant activity by increasing the immobility time of mice in forced swim test. The extract was not showed significant skeletal muscle relaxation in mice. Significant increase in onset of paw licking to heat stimuli in Eddy’s hot plate method and increase in reaction time to tail withdrawal in tail immersion test confirms the analgesic activity of extract. The dose dependent response was recorded in all models. Results obtained from present study revealed that the ethanolic extract of Adiantumcapillusveneris (L) possess significant neuropharmacological properties. The extract at dose 400 mg/kg body weight was found to be more effective.
