Parkinson's disease is characterized by dopaminergic-cell loss in the substantia nigra in the basal ganglia. Natural dietary antioxidants may exert protection against age-related deficits in cognitive and motor function. Present work conducted to evaluate the effects of some natural products in animal model of Parkinsonism which induced by rotenone injection (1.5 mg/kg s.c). Rats divided into 6 groups: - 1stcontrol: rats injected with rotenone 6 doses every other day for 11days, 2nd normal: rats injected i.p. with 1% cremophor, , injected s.c. DMSO. 3rd, 4th, 5th, 6th: rats given deprenyl (10 mg/kg, s.c), naringenin (50 mg/kg, p.o), harmine (5 mg/kg, i.p) & adenosine (500 mg/kg, i.p) 6 doses every other day for 11 days, 1 hour before rotenone injection. 24th after the last doses of all treatments, behavioural tests, rotarod and activity cage performed .At the end of the experiment, rats decapitated and brain removed for determination of brain neurotransmitters content as dopamine and its metabolite [dopamine (DA), 3,4 dihydroxyphenylacetic acid (DOPAC) and homovanilic acid (HVA)] and oxidative stress biomarkers as glutathione, malondialdehyde, nitric oxide (NOx) content . Results revealed that deprenyl and naringenin improved rats' locomotor activity, while, harmine and adenosine decreased the locomotor activity. Deprenyl, harmine, naringenin improved rats balancing time. Deprenyl and naringenin increased the dopamine content. Deprenyl, naringenin, harmine and adenosine treatment resulted in increased glutathione with decrease of malondialdehyde brain content. These findings suggested that all three tested agents improved the oxidative status induced by rotenone, however, naringenin and harmine counteracted the decrease in dopamine content.
