Human unsaturated fat synthase (FASN) is a 270-kDa cytosolic dimeric catalyst that is answerable for palmitate combination. FASN is gradually rising and rediscovered as a marker for the determination and anticipation of human malignancies. Ongoing examinations indicated that FASN is an oncogene and hindrance of FASN adequately and specifically slaughter malignancy cells. With late distributions of the FASN precious stone structure and the new improvement of FASN inhibitors, focusing on FASN opens another lucky opening for metabolically fighting malignancies. In this article, we will audit fundamentally the ongoing indications of progress in understanding the structure, capacity, and job of FASN in malignancies and pharmacologically focusing on FASN for human disease treatment.