Recent innovation in nanotechnology has shown wonderful promise to revolutionize drug delivery applications by generating novel ‘nano-deliveries’ that might allow more efficient targeted delivery of various drug molecules, which will reduce or limit systemic side-effects and allow for more efficient use of the drug. But prior to application of them, considerable challenges related to clinical toxicities should be taken into consideration. This review will focus on the various new drug delivery approaches in the context of advances in nanotechnology.