Objective: The aim of the present work was to develop and evaluate an oral nanogel for brushing containing clove oil and tannic acid with antimicrobial/antibacterial activity which will cure/protect from various periodontal diseases such as periodontitis, gingivitis and pyorrhea. The novelty of the work is combination of the components and its delivery via nanogel formulation technology.
Method: There are so many methods are used to prepare the nanogels. Some of them are
• Photolithographic techniques
• Fabrication of biopolymers
• Micro molding method
• Water-in-Oil (W/O) heterogeneous emulsion methods
• Inverse (mini) emulsion method
• Reverse micellar method
• Membrane emulsification
• Chemical cross linking
• Carbodiimide coupling
• Heterogeneous free radical polymerization
• Precipitation polymerization
• Dispersion polymerization
• Inverse (mini) emulsion polymerization
• Inverse microemulsion polymerization
• Heterogeneous controlled/living radical polymerization
• Reversible Addition Fragmentation Transfer (RAFT) process
Outcomes and significance: The novel nanogel form represents an effective and better carrier for the dental preparations. Nanogels based materials have high drug loading capacity, biocompatibility, and biodegradability which are the key points to design a drug delivery system effectively. It has a wide spectrum of antibacterial activity against a number of periodontal pathogens; hence it is selected for the treatment of periodontitis.
