Widespread therapeutic uses of dietary intervention include everything from the treatment of neurological conditions to efforts to lengthen life. The alteration in energy metabolism is the most significant result of different diets. Due to the fact that muscles account for 40% of the body's total mass and are one of the primary locations for absorbing glucose and energy, different diets predominantly affect their metabolism, resulting in both favorable and unfavorable changes to physiology and signaling pathways. In this review, we explore the potential effects of fasting, exogenous ketone body administration, and low-carbohydrate, high-fat diets (KD) on the energy metabolism of muscles. These interventions are all prospective therapeutic modalities for the management of a variety of disorders. The main effects of KD on muscle are seen in modifications to energy metabolism, specifically reduced carbohydrate and enhanced fat oxidation
