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Multi Component Reactions (MCRs) as a Green Approach Towards the Synthesis of Xanthene Derivatives, an Important Heterocyclic Nucleus of various Dyes and Drugs: A mini review | Abstract
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Abstract

Multi Component Reactions (MCRs) as a Green Approach Towards the Synthesis of Xanthene Derivatives, an Important Heterocyclic Nucleus of various Dyes and Drugs: A mini review

Author(s): G. M. Nazeruddin, A.A.Shaikh and Y.I.Shaikh.

Multi component reactions (MCRs) have been exploited for the synthesis of Xanthene derivatives using various catalysts under different reaction conditions such as Silica sulfuric acid (SSA) or Amberlyst-15 as an efficient and reusable heterogeneous catalyst has been used for the preparation of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthene-11-one derivatives from the threecomponent condensation reaction of b-naphthol, cyclic 1,3 dicarbonyl compounds and aromatic aldehydes under solvent-free conditions in good to excellent yields and short reaction times. Microwave Promoted Perchloric Acid catalyzed One Pot Synthesis of 14-aryl –14H - dibenzo[a,j] xanthene and 12-aryl-8, 9, 10, 12-tetrahydrobenzo[a]-xanthen-11-one derivatives by condensation of various substituted benzaldehydes , β-naphthol and dimedone under solvent free conditions. Similarly condensation of β-naphthol, aromatic aldehydes and cyclic 1,3- dicarbonyl compounds in presence of Chlorosulphonic acid (ClSO3H) as a catalyst to furnish 12-Aryl -8,9,10,12-tetrahydrobenzo [a]xanthen-11-ones derivatives in good to excellent yields under ultrasound and solvent free conditions at ambient temperature . All these methodologies are efficient and environmentally benign and can be developed further for industrial application.