The behavior of ultrasonic wave propagation through liquid solution has become an important tool for studying physical and chemical properties of liquid solutions. The density and viscosity of aqueous Dextran have been measured with different concentrations and ultrasonic velocities have been measured at different concentrations as well as at four different frequencies within range 1-12MHz at 313 K. From the experimental data various thermo acoustical parameters such Acoustic impedance (Z), Adiabatic Compressibility (β), Intermolecular free length (Lf), Relaxation time (τ) and Gibb’s free energy(ΔG) have been calculated. Molecular interactions in aqueous Dextran in terms of these thermo-acoustical parameters have been discussed.