This study was carried out to investigate the effects of ethyl acetate and n-butanol fractions of Indigofera pulchra on liver enzymes and lipid profile in alloxan induced diabetic rats. 20 Wistar rats of both sexes were used for the study. The rats were divided into four groups with five rats in each group. Group 1 and 2 representing negative and positive control respectively. Group 3 and 4 received 50 mg/kg and 250 mg/kg body weights of ethyl acetate and nbutanol respectively. After 14 days of treatment, the animal were anaesthetized and sacrificed to obtain blood by cardiac puncture. Serum was collected and assayed for alanine aminotranferase (ALT) aspartate aminotranferase ( AST) alkaline phosphatise(ALP)total protein ( TP), albumin (ALB), total cholesterol, triacylglycerol , high density lipoproteins and low density lipoproteins. The result showed that ALT,AST, TP and ALB levels of the treatment groups decrease(P<0.05) when compared with the ccontrol untreated group( Negative control) . As regards to the lipid profile there was a significant decrease (P<0.05) in the triacylglycerol, when compared with the untreated control group. Also in relation to the High density lipoprotein and low density lipoprotein there was a slight increase but no significant. The preliminary phytochemical screening of the two fractions Indigofera pulchra fractions revealed the presence of alkaloids, flavonoids, and saponins. The LD50 was 775mg/kg and 2,154 mg/kg for Ethylacetate and n-Butanol fractions respectively
