Cyanobacteria are having the potential for the development of effective adaptive mechanism during their three billion years of evolution. They are capable of performing oxygenic photosynthesis which is similar to eukaryotic algae and plants. They are considered to be a good model system for studying plant responses to environmental stress. The strain Synechocystis sp. PCC 6803 which is a salt sensitive mutant was used as a model organism in many laboratories to study the salinity adaptations. The unicellular cyanobacterium Synechocystis sp.PCC 6803 was grown in BG 11 medium as a batch culture with different concentration of NaCl. The results of analyzed various biochemical parameters were conform that the accumulation of chlorophyll a and proline content in salt adopted cells. Furthermore in the fatty acid composition, out of 11 fatty acids eight were saturated and three of them were unsaturated fatty acids in gas chromatography. In salt adopted cells the modification of fatty acid composition was understand in this studies.