Schiff bases have a wide range of applications such as corrosion inhibitor, intermediates in various reactions, in perfumery etc. Some are known to be used in many potential drugs and are known to possess broad spectrum of biological activities such as antiviral, antifungal, antiparasitic, antibacterial, anti-inflammatory. It can be synthesized by Microwave irradiation. Reaction of 6-methoxy-1, 3-benzothiazol-2-amine with substituted aldehydes under microwave irradiation (M.W.) gave the corresponding imines (Schiff bases). The structure of all the synthesized compounds was elucidated on the basis of IR, 1H NMR and mass spectral data.