The 2-iminothioethyl ether derivative of 3 underwent smooth nucleophilic displacement reaction with variety of hetryl amines and affored 4-9 in excellent yield. In this communication the importance of the incorporation of some pharmacophores such as 2-amino pyridinyl, pyrimidinyl, and benzothiazolyl in 1,4-benzodiazepine nucleus was highlighted.
