The pathogenesis and defensive mechanisms of Mycobacterium tuberculosis depend heavily on the human immune system (Mtb). This investigation looked at how people with Pulmonary Tuberculosis (PTB) changed their immune systems. In PTB patients, the immune system’s outward signs were altered; the infection’s inflammatory response was constrained, which reduced innate immune activation, and an increase in T and B cell responses served as the primary means of pathogen eradication.