This study was designed to investigate the effect of diabetes on liver injury (distant organ) induced by renal Ischemia Reperfusion injury (IR) in rat. Diabetes Mellitus type-II (DM-II) in rats were induced by administration of nicotinamide (230mg/kg, i.p.), 15 min prior, to the single dose of streptozotocin (STZ) (65mg/kg, i.v.). In vivo renal IR was performed in both type-2 diabetic and normal rats. Each protocol comprised ischemia for 30 min followed by reperfusion 24 hrs. The lipid peroxidation, xanthine oxidase activity, myeloperoxidase activity and nitric oxide level in liver tissue were significantly increased after IR in diabetic rats compared to nondiabetic rats. Antioxidant enzymes like glutathione superoxide dismutase, catalase and glutathione peroxidase were significantly reduced after IR in diabetic rats compared to normal rats. Diabetes type-II had exaggerated remote organ injury (liver) induced by renal IR injury in diabetes.
