The present study was aimed to find out the effect of Nematode (Aspiculuris tetraptera) parasite on lipid profile level (Triglyceride, Cholesterol, HDL and LDL) of mice infected and treated with Aqueous and Methanol extract of Termanalia arjuna bark. The mice carrying heavy infection showed decrease in the lipid profile level but after drug (Aqueous and Methanol extract of Termanalia arjuna bark) treatment lipid profile level was become on normal range due to killing of worm by drug. Methanol extract of Termanalia arjuna is more effective than aqueous extract of Termanilia arjuna