The study was aimed to assess the molluscicidal and cercaricidal potential of Artemisia annua leaves under laboratory conditions. The LC50 values of different crude extracts were tested for their molluscicidal activity against immature (Group I), young mature (Group II) and adult (group III) stages of Indoplanorbis exustus using Probit analysis. Snail size and different extracts of Artemisia annua strongly influenced the pattern of mortality and it was observed to be toxic to all the size/age classes of snails. Of the three extracts tested, carbon tetra chloride was most toxic against all the age classes (I, II, III) with the LC50 of 8.14ppm, 8.65ppm and 5.93ppm respectively. All the extracts also exhibited cercaricidal properties against two distome cercariae and the values were fairly below the molluscicidal range thus complementing a target specific approach towards control of trematodal infections.