The anti-inflammatory property of Kodasuri Veeravaippu was studied on rats by inducing Carrageenan induced paw edema and cotton pellet induced granuloma. Kodasuri veeravaippu was prepared by standard sidha medical methodology. Diclofenac sodium was administered orally at a dose of 5 mg/kg to Wistar strain rats which were positive control group. To the negative control group Normal saline 5 ml/kg was given orally. 9.75 mg, 13 mg and 16.25 mg of Kodasuri veera vaippu per kg were given orally as low, medium and high dose respectively. After 30min 0.1ml 1% Carrageenan was injected into the plantar region of left paw of all groups. The paw volume was measured at 0, 60, 120, 180, 240, 300 min after Carrageenan administration. The percentage difference in left and right paw was calculated. For cotton pellet granuloma study sterile pre-weighed cotton pellets (50±1 mg) were implanted in the axillary region of each rat through a single needle incision. ‘Kodasuri veeravaippu’ (9.75 mg, 13 mg and 16.25 mg), positive controls (Diclofenac sodium 5 mg/kg) and negative control (Normal saline 5 ml/kg) were administered to the respective group of animals for seven consecutive days from the day of cotton pellet implantation. On the eighth day, the animals were anaesthetized again; the cotton pellets were removed surgically and made free from extraneous tissues. The pellets were incubated at 37°C for 24 hours and dried at 60°C to obtain constant weight. The increment in the dry weight of the pellets was regarded as a measure of granuloma formation. The results clearly indicate that sidha preparation, Kudasuri Veeravaippu should be used as an effective antiinflammatory drug which gave better results compared to diclofence sodium.
