Many species of the genus Morinda are found to be rich in secondary metabolites having a medicinal value.Morinda Pubescence (Rubiaceae) is a medicinally important plant being used in different indigenous systems of medicine such as Ayurveda, Siddha, Unani, Tibbi and Amchi. Extract of its leaves, stems and fruits are used as traditional remedy for various diseases such as in the treatment of gastropathy, dyspepsia, diarrhoea, stomach ulcer, wounds, gout, inflammation, hernia, sarcocele etc. Selective solvent extractions‚steam distillation, chromatography, preparative TLC along with mixed solvent system for crystallization were the major techniques used for isolation of compounds, while structures were elucidated by integration of data from IR, UV, 1H NMR and 13C NMR analysis and analysized by DFT technique. The presence of para-hydroxy quinone was accounted first time from the leaves of M. Pubescence