Der Pharmacia Lettre
Abstract
Author(s): Shivani Singh, Satyam Gangwar, Garima Garg, Vipin Garg, P.K.Sharma
In the present study the mucilage obtained from bay leaves [cinnamomum tamala Nees
(lauraceae)] was used as binder for the formulation of paracetamol tablets. The physicochemical
characterization of mucilage was done and the % swelling capacity of mucilage was found to be
33.2%. Mucilage was also characterized by FTIR spectroscopy as well as qualitative
phytochemical screening. Mucilage showed the presence of tannins and sugars. Five batches of
paracetamol tablets were prepared using three different concentrations (5, 10 & 15%) of
mucilage, PVP & starch as binder. From in-vitro release data it was observed that bay leaves
mucilage posses good binding property similar to commercial pharmaceutical binders in the
concentration range between 10 to 15%. Tablets were also evaluated for hardness and friability
and the friability values for all the tablets was found to be less than 1% and thus showing good
binding property.
