Isatin has been recently found to exhibit endogamous activity in mammals. In recent years schiff’s and Mannich bases of isatins are reported to exhibit broad spectrum chemotherapeutic properties such as antibacterial, anti HIV, antiviral, anticonvulsant, antitubercular and anticancer. So far, modifications of the isatin ring have proven highly effective with improved potency and lesser toxicity. The present review highlights the recently synthesized isatins possessing important biological activities.
