The objective of the present investigation was to found the effect of gums as binders namely
acacia, tragacanth, guar gum, gum karaya and gum olibanum on the disintegration, dissolution
rate and other qualities of Ziprasidone tablets. Based on dissolution rate (k1) and dissolution
efficiency (DE60) values the order of performance of binders was gum karaya > acacia > gum
olibanum > tragacanth > guar gum. Among all gum karaya and acacia gave significantly higher
dissolution rate and DE60. Good correlation (r = 0.934) was observed between disintegration
times and dissolution characteristics of various tablets.
