Chalcones, precursors of open chain flavonoids and isoflavonoids present in edible plants, and their derivatives have attracted increasing attention due to numerous potential pharmacological applications. They have displayed a broad spectrum of pharmacological activities. Changes in their structure have offered a high degree of diversity that has proven useful for the development of new medicinal agents having improved potency and lesser toxicity. The present study highlights synthesized chalcones and their derivatives possessing important pharmacological activities. It involves synthesis of some novel chalcones and find out the potency against antimicrobial and antioxidant activity by DPPH method.