The bioefficacy of the lichen substances of R. farinacea (L.) Ach and P. acetabulum (Neck.) Duby is evaluated against adults of the Mediterranean fruit fly Ceratitis capitata Wied., considered one of the most important pests of fruit crops. By performing a fumigation test, we found that these two extracts of lichens reveal a very highly significant insecticidal effect on the adults of the fruit fly. We obtained 100% adult mortality after 48 hours of exposure to the dose of 20 μl/L air of R. farinacea extract and at this same dose of P. acetabulum extract we obtained 100% adult mortality after 96 hours (20 μl/L of air are taken from lichen acetone extract with a concentration of 0.03 mg plant pouder per 1 μl of acetone)