In this study we tried to investigate the effect of Melissaofficinalis and Tanacetumbalsamita extract on performance and serum composition of Japanese quails. One week old of 400 Japanese quails were divided into 4 groups and 5 repetitions with 20quails each. First group ,TG1, control group did not receive any herbal planet extract, second group ,TG2, fed 200ppm of melissaofficinalis extract, third group ,TG3, fed 200 ppm oftanacetumbalsamita extract, and group of 4,TG4, fed 2% of both herbal planet. The results showed that using these two medicinal plants in their diet had significant effects on performance, carcass traits and blood biochemical parameters ofjapanese quails (p<0.05).The best result for FCR was in group 2 and The highest amount of daily feed intake andaverage daily gain were observed in the G4 and the highest percent of breast and gizardwereobserved in group of 4 but the highest percent of spleen was in TG3. Also the serum total cholesterol and triglycerides concentration were significantly reduced in groups of 4 compared to the control group (P<0.05) but there is not any significantly effects on other blood parameters.