An experiment was conducted to assess the effects of replacing sodium selenite (SS) by Se-yeast (SY) in diet on growth performance and selenium and vit E contents in male broilers tissue.One day-old 240 male birds were randomly assigned to 4 treatments with 4 replicates of 15 birds each. The experimental grower diets that were supplemented with SS or SY at 0.3 mg Se/kg of feed, as follows: T1= 0.3 SS, T2= 0.2 SS+0.1 SY, T3= 0.1 SS+0.2 SY, and T4= 0.3 SY were given ad libitum to the birds during a 21 d-old grower period. The basal diet was also, supplemented with 75 mg of vitaminE. SY enrichment of grower diets increased(P ≤ 0.05) both contents of Se and vitamin E in breast and thigh tissues and increased the weight of live chickens significantly (P < 0.01). Also, birds fed 3% SY (T4) diet had better (P ≤ 0.05) feed conversion ratio (FCR) compared to the others treatments. The mortality rate was lowest in T3 and T4.