In this study we tried to investigate the effect of dietary garlic and sumac (RhusCoriariaL.)powder on performance and serum composition of Japanese quails.In this study that startedone week following until 42 days there are five treatments and five replicates, at first 375,7 day old quails were divided to 25 groups of 15 quils each. Each 5 groups randomly assigned to one of the 5 treatments. Experimental groups included Q1, control group, Q2,basal diet containing 2% sumac powder,Q3, using 2% of garlic powder, Q4, fed by basal diet plus 2%garlic and sumac powder. Results showed that the highest feed conversion rate was in control group but the lowest FCR was in Q4 (P< 0.05). The highest amount of daily feed intake was observed in the group 2 and the lowest group was observed in control group also the highest carcass and liver percentage were in Q4 and Q2 respectively (P<0.05).The lowest level of total cholesterol (Chol) and triglyceride (TG)were in Q3. All results showed that using sumac and Garlic powder have positive effects on performance, carcass traits and blood biochemical parameters of Japanese quails.