Nefang is a polyherbal preparation constituted of the leavesof six plants and the bark of one of these,used traditionally for the treatment of malaria by the Bayang community, South West Region of Cameroon. Since no ethnopharmacological survey has been carried out on this preparation, this study aims at obtaining indigenous and folkloric information on the optimal methods for harvesting of constituent plants, preparation and administration of Nefang in the treatment of malaria. The study design was an exploratory survey.Semi-structured questionnaires were administered randomly to 20 respondents after obtaining their informed consent with the assistance of a medical practitioner. Review of literature of constituent plants was also undertaken. This study revealed that the respondents had a good knowledge of malaria and its causes. Various compositions for the preparation by decoction was obtained and administration was ascertained to be by oral route or by enema. The brief scientific review also validated the pharmacological actions of the constituent plants. The diverse indigenous knowledge and folk use of this preparation in the treatment of malaria are a pre-requisite for theoptimization of its compositionfor efficacy and pharmacological screening.