Fast dissolving tablet (FDT) is commonly used and mostly accepted dosage form due to its various advantages over the other dosage forms. The important component of the FDT is superdisintegrant. There are various natural as well as synthetic superdisintegrant are available and used in formulation. The objective of present work was to find out the alternative for the synthetic superdisintegrant. Which gives cost effective formulation with minimized the drug and excipient interaction. For that the area selected for the study was natural superdisintegrant. In this study the “Ground Nut Shells” i.e. “Peanut Shells” were powdered (GNSP) and investigated for its superdisintegrant property by using the Tramadol Hydrochloride as a model drug. In present study the GNSP was prepared and evaluated for its physicochemical property, phytochemical study, flow property and Particle size analysis. After successful drug and excipient compatibility study with FT-IR and DSC analysis the tablets were prepared by direct compression method by using GNSP in various concentrations 3.33%, 6.66% & 10 % of GNSP by using factorial design. All formulations were evaluated for weight, thickness, hardness, friability, drug content, wetting time, in vitro dispersion, in vitro dissolution study and results obtained were found satisfactory and from that we conclude that the GNSP has significant superdisintegrant potential.
