This study was aimed to investigate the phytochemical constituents and hepatoprotective activity of Cleome viscose seeds extract on CCl4 induced hepatotoxicity. Hepatotoxicity was induced in normal albino rats. CCl4 was administered orally at a dosage of 20mg/kg body weight in physiological saline for 1 day. The rats were divided into five groups comprising of four rats each. Group I Normal control. Group II Disease control CCl4 (20 mg /kg b.w). Group III Animals treated with the aqueous extract of Cleome viscosa seeds (150mg/Kg body weight orally) for 14 days. Group IV Animals treated with the aqueous extract of Cleome viscosa seeds (300mg/Kg body weight orally) for 14 days. Group V Animals treated with standard drug Silymarin (20mg/Kg body weight orally) for 14 days. After completed the experiment, the liver markers, lipid profile and antioxidants were analysed. Phytochemical screening of aqueous extract of Cleome viscosa seeds indicates the presence of flavonoids, tannins, glycosides, phenol, steroids, alkaloids, quinone, saponin and coumarin. Supplementation of Asteracantha longifolia significantly restored the liver markers, lipid profile and antioxidant markers on in CCl4 induced Wistar albino rats. The results of our study showed that Cleome viscosa seeds possess significant hepatoprotective and antioxidant activity, probably due to its phytochemicals.
