A systemic and scientific investigation of aqueous extract of Girardinia hetrophylla for its antioxidant and hepatoprotective potential against ethanol induced hepatic damage in mice was carried out. Antioxidant property was assessed by using reducing property, superoxide anion scavenging and hydroxyl radical scavenging property. Hepatoprotective property was assessed by measuring the extent of reversal of enhanced biochemical marker for liver such as serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), bilirubin and also by estimating the tissue Glutathione (GSH), Superoxide dismutase(SOD), Catalase and the tissue lipid peroxidation levels. Aqueous extract of Girardinia hetrophylla at the dose of 1600mg/kg produced significant hepatoprotective effect by decreasing the serum enzymes, bilirubin and tissue lipid peroxidation while it significantly increased the levels of tissue GSH, SOD and catalase.
