Der Pharmacia Lettre
Abstract
Author(s): Shashikant D. Barhate, Tejaswita N. Gholap
The aim of the present work was to develop and evaluate a transdermal bioadhesive transdermal
film containing indapamide. Indapamide is a long-acting hypertensive with both diuretic and
vasodilative actions and is defined by the 1999 WHO/ISH Hypertension Guidelines as a first-line
drug for the treatment of hypertension. Transdermal films were prepared by dissolving in water
Eudragit RS100, lauric acid, adipic acid, polyvinyl alcohol, sorbitol and indapamide. The
resultant mixture was spread on siliconized paper and dried. The in-vitro permeation
experiments were performed in Franz-diffusion cell using freshly excised rat skin for 12 h. The
permeation results of indapamide form 2 mg/ml and 5mg/ml solutions in phosphate buffer (pH
7.4) showed significant permeation behaviour. The in vitro permeation results of transdermal
films showed good permeation characteristics across the skin, with linear release from film F3.
The Eudragit RS 100 and polyvinyl acetate in 1:2 proportions proved to be better composition
for preparation of transdermal film which can be a promising and innovative therapeutic system
for indapamide.
