Der Pharmacia Lettre
Abstract
Author(s): Manjul Pratap Singh, Gulzar Alam, Roshan Patel, Upendra Kumar, Anita Singh
Sodium alginate beads were evaluated as sustained release vehicles for the delivery of
Riboflavin. It has been shown that the structure of the cross-linked calcium alginate network is of
primary importance in the retention and/or release of the Riboflavin. The Riboflavin bead
formulations were prepared by dispersing Riboflavin together with a mixture of sodium
alginate and plasticizer solution and then dripping the dispersion into a solution of 5% (w/v)
calcium chloride for different time of cross linking. Prepared beads were evaluated for Particle
size, Flow property, Drug entrapment efficiency and in-vitro drug release. The formulations
showed the particle size and angle of repose within acceptable range having good flow property
but the beads formed by high cross linking time demonstrated nearly same particle size and
showed poor flow property as compared with other formulations. Drug entrapment efficacy of
all formulations was in the range of 55.76 - 74.21% and entrapment efficacy of beads decreases
with increase the cross linking time. Riboflavin in-vitro release from beads was studied. The
Beads prepared by maximum 15 minutes cross linking time shows 77% drug release. The values
of coefficient correlation were calculated and drug release was found to follow Higuchi matrix
order release.
